Collaborative Studies in an Animal Model for Pancreatic Cystic Neoplasia

Using Dr. Maitras recently generated animal model of pancreatic cystic neoplasia, the collaborative team will perform basic cancer biology and translational cancer biomarker studies in a mouse model that can be extrapolated to human intraductal papillary mucinous neoplasms (IPMN) cohorts. The team will elucidate the global epigenomic, transcriptomic and protoemic alterations underlying the compound mutant Kras;Gnas model of pancreatic cystic neoplasia, identify circulating biomarkers of progression to invasive pancreatic ductal adenocarcinoma (PDAC) using the Kras;Gnas model of cystic neoplasia, and identify aberrantly expressed tumor-associate antigens as the potential basis of precision immunotherapy.