Johns Hopkins Molecular and Cellular Characterization Laboratory (Prostate)

Using a large institutional database of patients who have undergone radical prostatectomies, Dr. DeMarzo and multi-disciplinary team will develop integrated genomic, epigenetic and expression profiling signatures of indolent and aggressive prostate tumors in both white and African American men. Molecular biomarkers will then be validated using immunohistochemistry and/or in situ hybridization, and further validated in relation to patient outcomes, to yield novel biomarkers that can be used in clinical practice to guide appropriate treatment and reduce overtreatment.