Longitudinal molecular and microenvironment evaluation of squamous cell pulmonary premalignancy

Assessing archival lung squamous cell carcinoma cases that have premalignant lesions and prospectively collected pulmonary premalignant lesions, MCL investigators will identify molecular changes in premalignant pulmonary lesions in longitudinal setting using whole exome sequencing, gene expression profiling and multiplex immunofluorescence profiling of immune modulators in adenocarcinoma tumors and the associated premalignancies. Discovering critical neoepitopes and identifying longitudinal modulations in targetable neoepitopes and mediators of cellular immunity in pulmonary premalignancy will facilitate vaccine development for patients at the highest risk for progression to invasive lung cancer, transforming therapy and improving patient outcomes.
Steve Dubinett