MCL Supplement: A Pre-Cancer Atlas (PCA) for Breast, Lung, Pancreas, and Prostate Pilot Project

Characterization of molecular alterations in precancerous lesions and the corresponding microenvironment in four major organ sites in order to uncover the molecular and cellular determinants of premalignancy and establish standardized sequencing and immunohistochemistry protocols on FFPE precancerous tissue. Evaluation of the technical feasibility of single nuclei sequencing of small FFPE pre-cancer lesions. Successful completion of the proposed pilot study sets the stage for expansion and development of a comprehensive Pre-Cancer Atlas (PCA) as part of the NCIs Cancer Moonshot Program.
Liz Moses