Vanderbilt Molecular and Cellular Characterization Laboratory (Lung)

Dr. Massion and team will integrate quantitative structural image analysis, single cell and molecular analysis of early stage adenocarcinoma of the lung from screen- or incidentally-detected lung nodules to improve discrimination of indolent from aggressive cancers and develop optimal approaches of intervention. Their approach includes collection, integration and analysis of clinical, structural imaging, cellular and molecular attributes of screen-detected non-solid, part-solid, and solid malignant modules as well as non-screen detected lung adenocarcinomas to discover biological determinants of indolent tumor behavior. They aim to impact clinical interventions for both indolent and aggressive tumors and develop strategies to avoid morbidities associated with overdiagnosis in lung cancer screening efforts.